陈剑(博士,副研究员)

  男,1980年生,中国药科大学生药学博士,2010年赴比利时根特大学联合培养并获得化学专业博士学位,2016年获江苏政府留学奖学金资助前往加州大学洛杉矶分校访学研究;现任江苏省中国科学院植物研究所副研究员,药用植物研究中心副主任,抗糖尿病植物项目组组长;南京林业大学硕士生导师,南京中医药大学硕士生导师,入选2017年度江苏省“双创博士”计划。

  主要从事药用植物尤其是防治代谢综合征特色中草药的活性成分发掘、功效评价及作用机制研究。先后主持国家自然科学基金面上项目、青年基金,江苏省自然科学基金、江苏省重点研发计划等各类科技计划12项;在国内外刊物上发表相关科研论文69篇,其中SCI论文37篇;获授权国家发明专利15件;获盐城市科技进步二等奖1项。

  联系方式 E-mail: chenjian80@aliyun.com  Tel: 025-84347081

  一.主持和参与项目(近五年)

  1. 国家自然科学基金面上项目,81973463,菊苣抗糖尿病活性组分调控肠道菌群微生态的变化及其作用机制研究,2020/01-2023/12,55万元,在研,主持。
  2. 国家自然科学基金面上项目,81773885,基于肠道菌群靶点和代谢组学方法探讨枇杷叶新颖倍半萜改善T2DM胰岛素抵抗的作用研究,2018/01-2021/12,55万元,在研,主持。
  3. 国家自然科学基金面上项目,31770366,基于化学物质组和代谢组学方法探讨菊三七属降糖植物效应物质基础与作用机理的异同,2018/01-2021/12,60万元,在研,参加。
  4. 国家自然科学青年基金项目,31400287,耐盐碱中药二色补血草中抗肿瘤有效成分的积累及其资源品质评价,2015/01-2017/12,25万元,已结题,参加。
  5. 江苏省创新能力建设计划暨中央引导地方科技发展专项,江苏省抗糖尿病药物筛选技术服务中心,2019/01-2021/12,50万元,在研,主持。
  6. 江苏省自然科学基金面上项目,BK20141387,枇杷叶活性倍半萜苷改善胰岛素抵抗与改变肠道菌群结构相关性研究,2014/07-2017/06,10万元,已结题,主持。
  7. 江苏省重点研发计划-现代农业项目,BE2016383,菱角壳的资源化综合利用技术研究,2016/07-2019/06,50万元,已结题,参加。
  8. 江苏省重点研发计划-社会发展项目,BE2015690,枇杷叶药渣和枇杷落叶的资源化利用技术研究,2015/07-2018/06,50万元,已结题,参加。
  9. 江苏省“双创博士”,江苏省人才工作领导小组办公室,2017年12月。
  10. 2015年度太仓科技领军人才,太仓市人民政府,2016年2月。

  二.代表性研究论文(近五年)

  1. Tunyu Jian, Jian Chen*, Xiaoqin Ding, Han Lv, Jiawei Li, Yuexian Wu, Bingru Ren, Bei Tong, Yuanyuan Zuo, Kelei Su, Weilin Li*, Flavonoids isolated from loquat (Eriobotrya japonica) leaves inhibit oxidative stress and inflammation induced by cigarette smoke in COPD mice: the role of TRPV1 signaling pathways, Food & Function, 2020, DOI: 10.1039/c9fo02921d
  2. Xiaoqin Ding, Tunyu Jian, Yuexian Wu, Yuanyuan Zuo, Jiawei Li, Han Lv, Li Ma, Bingru Ren, Lei Zhao, Weilin Li*, Jian Chen*, Ellagic acid ameliorates oxidative stress and insulin resistance in high glucose-treated HepG2 cells via miR-223/keap1- Nrf2 pathway, Biomedicine & Pharmacotherapy, 2019, 110: 85-94
  3. Tunyu Jian, Han Lü*, Xiaoqin Ding, Yuexian Wu, Yuanyuan Zuo, Jiawei Li, Jian Chen*, Hong Gu, Polyphenol-rich Trapa quadrispinosa pericarp extract ameliorates high-fat diet induced non-alcoholic fatty liver disease by regulating lipid metabolism and insulin resistance in mice, PeerJ, 2019, 7: e8165
  4. Yanan Gai, Yingshuo Li, Zenglai Xu, Jian Chen*, Pseudoprotodioscin inhibits SREBPs and microRNA 33a/b levels and reduces the gene expression regarding the synthesis of cholesterol and triglycerides, Fitoterapia, 2019, 139: 104393
  5. Tianyu Han, Mimi Li, Jiawei Li, Han Lv, Bingru Ren, Jian Chen*, Weilin Li*, Comparison of chloroplast genomes of Gynura species: sequence variation, genome rearrangement and divergence studies, BMC Genomics, 2019, 20: 791
  6. Tunyu Jian, Yuexian Wu, Xiaoqin Ding, Han Lv, Li Ma, Yuanyuan Zuo, Bingru Ren, Lei Zhao, Bei Tong, Jian Chen*, Li Weilin, A novel sesquiterpene glycoside from loquat leaf alleviates oleic acid induced steatosis and oxidative stress in HepG2 cells, Biomedicine & Pharmacotherapy, 2018, 97: 1125-1130
  7. Tunyu Jian, Xiaoqin Ding, Yuexian Wu, Bingru Ren, Weilin Li, Han Lv*, Jian Chen*, Hepatoprotective effect of Loquat leaf flavonoids in PM2.5-induced non-alcoholic fatty liver disease via regulation of IRs-1/Akt and CYP2E1/JNK pathways, International Journal of Molecular Science, 2018, 19: 3005
  8. Jian Chen, Han Lü, Lianxiang Fang, Weilin Li*, Luc Verschaeve, Zhengtao Wang, Norbert De Kimpe, Sven Mangelinckx*, Detection and toxicity evaluation of pyrrolizidine alkaloids in medicinal plants Gynura bicolor and G. divaricata collected from different Chinese locations, Chemistry & Biodiversity, 2017, 14(2): e1600221
  9. Tunyu Jian, Xiancan Ao, YueXian Wu, Han Lv, Li Ma, Lei Zhao, Bei Tong, Bingru Ren, Jian Chen*, Weilin Li*, Total sesquiterpene glycosides from Loquat (Eriobotrya japonica) leaf alleviate high-fat diet induced non-alcoholic fatty liver disease through cytochrome P450 2E1 inhibition, Biomedicine & Pharmacotherapy, 2017, 91: 229-237
  10. Jian Chen, Jiehui Teng, Li Ma, Haiying Tong, Bingru Ren, Linshan Wang, Weilin Li*, Flavonoids isolated from the flowers of Limonium bicolor and their in vitro antitumor evaluation, Pharmacognosy Magazine, 2017, 13: 222-225
  11. Jian Chen, Sven Mangelinckx, An Adams, Zhengtao Wang, Weilin Li*, Norbert De Kimpe*, Natural flavonoids as potential herbal medication for the treatment of diabetes mellitus and its complications, Natural Product Communications, 2015, 10(1): 187-200
  12. Jian Chen, Sven Mangelinckx*, Han Lü, Zhengtao Wang, Weilin Li*, Norbert De Kimpe, Profiling and elucidation of the phenolic compounds in the aerial parts of Gynura bicolor and G. divaricata collected from different Chinese origins, Chemistry & Biodiversity, 2015, 12(1): 96-115
  13. Xiancan Ao, Lei Zhao, Han Lü, Bingru Ren, Hankui Wu, Jian Chen*, Weilin Li, New sesquiterpene glycosides from the leaves of Eriobotrya japonica, Natural Product Communications, 2015, 10(7): 1145-1147